On the etiology of incident brain lacunes: longitudinal observations from the LADIS study.

نویسندگان

  • Alida A Gouw
  • Wiesje M van der Flier
  • Leonardo Pantoni
  • Domenico Inzitari
  • Timo Erkinjuntti
  • Lars O Wahlund
  • Gunhild Waldemar
  • Reinhold Schmidt
  • Franz Fazekas
  • Philip Scheltens
  • Frederik Barkhof
چکیده

BACKGROUND AND PURPOSE We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.

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عنوان ژورنال:
  • Stroke

دوره 39 11  شماره 

صفحات  -

تاریخ انتشار 2008